Anti-Human CEACAM-1/CD66a Reference Antibody (MK-6018, RUO) (HB880026)

Name: Anti-Human CEACAM-1/CD66a Reference Antibody (MK-6018, RUO)
Brand: abinScience
SKU: HB880026
Price: 370 USD
Availability: InStock

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개요

카탈로그 번호	HB880026
설명	Anti-Human CD66a/CEACAM1 Antibody (MK-6018) (HB880026) is a research-grade recombinant antibody targeting CD66. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4
클론 ID	MK-6018
발현 시스템	Mammalian cells
타겟	CD66a, BGP-1, Biliary glycoprotein 1, CEACAM1, Carcinoembryonic antigen-related cell adhesion molecule 1, BGP, BGP1
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P13688
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Cell adhesion molecule CEACAM1 (CD66a) is a ~57 kDa protein. Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner. Plays a role as coinhibitory receptor in immune response, insulin action and also functions as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils. Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70. 1. Chen, Z. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 180, 6085-93. PMID: 18424730 2. Hosomi, S. et al. (2013) European journal of immunology 43, 2473-83. PMID: 23696226 3. Huang, YH. et al. (2015) Nature 517, 386-90. PMID: 25363763 4. Klaile, E. et al. (2005) Journal of cell science 118, 5513-24. PMID: 16291724
참고사항	For research use only. Not suitable for clinical or therapeutic use.