Anti-Human 5'-Nucleotidase/CD73 Reference Antibody (IBI-325, RUO) (HB209186)

Name: Anti-Human 5'-Nucleotidase/CD73 Reference Antibody (IBI-325, RUO)
Brand: abinScience
SKU: HB209186
Price: 370 USD
Availability: InStock

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100ug
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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HB209186

설명

Anti-Human CD73/NT5E (IBI-325) (HB209186) is a research-grade recombinant antibody targeting CD73.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.

종 반응성

Human

응용 분야

ELISA, FCM, Functional assay

숙주 종

Human

클론성

Monoclonal

이소타입

IgG4, kappa (F234A, L234A)

클론 ID

IBI-325

타겟

5'-NT, 5'-deoxynucleotidase, 5'-nucleotidase, CD73, EC:3.1.3.35, EC:3.1.3.5, EC:3.1.3.89, EC:3.1.3.91, EC:3.1.3.99, Ecto-5'-nucleotidase, IMP-specific 5'-nucleotidase, NT5, NT5E, NTE, Thymidylate 5'-phosphatase

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

P21589

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

5'-nucleotidase (CD73/NT5E) is a ~63 kDa protein. Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.

1. Garavaglia, S. et al. (2012) The Biochemical journal 441, 131-41. PMID: 21933152

2. Heuts, DP. et al. (2012) Chembiochem : a European journal of chemical biology 13, 2384-91. PMID: 22997138

3. Knapp, K. et al. (2012) Structure (London, England : 1993) 20, 2161-73. PMID: 23142347

4. Fausther, M. et al. (2014) PloS one 9, e98568. PMID: 24887587

5. Scaletti, E. et al. (2021) Purinergic signalling 17, 693-704. PMID: 34403084

참고사항

For research use only.

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