Anti-Human CD93/C1qR Reference Antibody (Dcby02, RUO) (HV345016)

Name: Anti-Human CD93/C1qR Reference Antibody (Dcby02, RUO)
Brand: abinScience
SKU: HV345016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HV345016
설명	Anti-Human CD93/C1qR Antibody (Dcby02) (HV345016) is a research-grade recombinant antibody targeting CD93. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
이소타입	IgG
클론 ID	Dcby02
발현 시스템	Mammalian cells
타겟	Matrix-remodeling-associated protein 4, C1q/MBL/SPA receptor, C1qRp, C1QR1, C1qR, Complement component 1 q subcomponent receptor 1, CD93, Complement component C1q receptor, MXRA4, CDw93, C1qR(p)
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q9NPY3
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	Dcby02, Dcby02, Dcby-02
배경	Complement component C1q receptor (CD93/C1qR) is a ~68 kDa protein. Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. 1. Geertsma, MF. et al. (1994) The American journal of physiology 267, L578-84. PMID: 7977768 2. Orlandini, M. et al. (2014) Oncotarget 5, 2750-60. PMID: 24809468 3. Galvagni, F. et al. (2016) Oncotarget 7, 10090-103. PMID: 26848865 4. Khan, KA. et al. (2017) Oncogene 36, 6097-6108. PMID: 28671670 5. Barbera, S. et al. (2023) International journal of biological macromolecules 224, 453-464. PMID: 36265539 6. Xu, Y. et al. (2024) Structure (London, England : 1993) 32, 282-291.e4. PMID: 38218180
참고사항	For research use only. Not suitable for clinical or therapeutic use.