Anti-Human Complement Factor B Reference Antibody (SAR-443809, RUO) (HF634026)

Name: Anti-Human Complement Factor B Reference Antibody (SAR-443809, RUO)
Brand: abinScience
SKU: HF634026
Price: 370 USD
Availability: InStock

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개요

카탈로그 번호	HF634026
설명	Anti-Human CFB Antibody (SAR-443809) (HF634026) is a research-grade recombinant antibody targeting Properdin factor B. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a, kappa
클론 ID	SAR-443809
발현 시스템	Mammalian cells
타겟	Properdin factor B, Complement factor B, GBG, Glycine-rich beta glycoprotein, BFD, C3/C5 convertase, CFB, PBF2, BF
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P00751
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Complement factor B (CFB) is a ~85 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes of the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways (classical, lectin and GZMK) by promoting formation of additional C3 and C5 convertases. CFB is cleaved and activated by CFD to generate Ba and Bb chains; Bb chain constituting the catalytic component of the C3 and C5 convertases. 1. Pangburn, MK. et al. (1986) The Biochemical journal 235, 723-30. PMID: 3638964 2. Vogt, W. et al. (1978) Immunology 34, 29-40. PMID: 624565 3. DiScipio, RG. et al. (1983) The Journal of biological chemistry 258, 10629-36. PMID: 6554279 4. Vogel, CW. et al. (1982) The Journal of biological chemistry 257, 8292-9. PMID: 6919543 5. Hourcade, DE. et al. (1998) The Journal of biological chemistry 273, 25996-6000. PMID: 9748277 6. Niemann, MA. et al. (1980) Biochemistry 19, 1576-83. PMID: 6769474
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)