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| 카탈로그 번호 | HW376016 |
|---|---|
| 설명 |
Anti-Human CXCL12/SDF-1 Antibody (Genentech anti-CXCL12) (HW376016) is a research-grade recombinant antibody targeting Intercrine reduced in hepatomas. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | Genentech anti-CXCL12 |
| 발현 시스템 | Mammalian cells |
| 타겟 | Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P48061 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Stromal cell-derived factor 1 (CXCL12/SDF-1) is a ~10 kDa protein. Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. 1. Malik, M. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 4632-7. PMID: 18802065 2. Liu, Y. et al. (2024) Cell reports 43, 114578. PMID: 39093700 3. Oberlin, E. et al. (1996) Nature 382, 833-5. PMID: 8752281 4. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 5. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 6. Fujita, M. et al. (2018) The Biochemical journal 475, 723-732. PMID: 29301984 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human CXCL12/SDF-1 Antibody (Genentech anti-CXCL12)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
