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| 카탈로그 번호 | HC564016 |
|---|---|
| 설명 |
Anti-Human DAG1/Dystroglycan (DAG-6F4) (HC564016) is a research-grade recombinant antibody targeting Dystrophin-associated glycoprotein 1. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | DAG-6F4 |
| 발현 시스템 | Mammalian cells |
| 성질 | Recombinant |
| 타겟 | Dystrophin-associated glycoprotein 1, DAG1, Alpha-DG, Dystroglycan, Beta-DG |
| 내독소 수준 | < 10 EU/mg as determined by LAL method. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q14118 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | DAG-6F4, DAG6F4, DAG6F4 |
| 배경 | Dystroglycan 1 (DAG1) is a ~97 kDa protein. The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis. Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells. Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation. 1. Eldridge, S. et al. (2016) Annals of the rheumatic diseases 75, 1228-35. PMID: 26290588 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human DAG1/Dystroglycan (DAG-6F4)
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