Anti-Human FGL1 Reference Antibody (SH-07, RUO) (HC338016)

Name: Anti-Human FGL1 Reference Antibody (SH-07, RUO)
Brand: abinScience
SKU: HC338016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HC338016
설명	Anti-Human FGL1 (SH-07) (HC338016) is a research-grade recombinant antibody targeting Liver fibrinogen-related protein 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1
클론 ID	SH-07
발현 시스템	Mammalian cells
타겟	Liver fibrinogen-related protein 1, HFREP-1, HP-041, Hepatocyte-derived fibrinogen-related protein 1, HPS, FGL1, LFIRE-1, Hepassocin, Fibrinogen-like protein 1, HFREP1
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q08830
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Fibrinogen-like protein 1 (FGL1/HFREP1) is a ~36 kDa protein. Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3. LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes. 1. Wang, J. et al. (2019) Cell 176, 334-347.e12. PMID: 30580966 2. Ming, Q. et al. (2022) Nature immunology 23, 1031-1041. PMID: 35761082 3. Jiang, Y. et al. (2025) Cell 188, 2354-2371.e18. PMID: 40101708 4. Hara, H. et al. (2001) Biochimica et biophysica acta 1520, 45-53. PMID: 11470158 5. Li, CY. et al. (2010) Gut 59, 817-26. PMID: 19880967
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)