中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB264016 |
|---|---|
| 설명 |
Anti-Human GP88/GRN (AG1) (HB264016) is a research-grade recombinant antibody targeting PC cell-derived growth factor. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | AG1 |
| 발현 시스템 | Mammalian cells |
| 타겟 | PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P28799 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | AG1 |
| 배경 | Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. 1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812 2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771 3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925 4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791 5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
SDS-PAGE for Research Grade Anti-Human GP88/GRN (AG1)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
