Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO) (HB251016)

Name: Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO)
Brand: abinScience
SKU: HB251016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HB251016
설명	Anti-Human ITGB6 (SGN-B6A) (HB251016) is a research-grade recombinant antibody targeting ITGB6. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-kappa
클론 ID	SGN-B6A
발현 시스템	Mammalian cells
타겟	ITGB6, Integrin beta-6
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P18564
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	SGN-B6A, SGNB6A, SGNB6A
배경	Integrin beta-6 (ITGB6) is a ~85 kDa protein. Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation. 1. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 2. Ramsay, AG. et al. (2007) Cancer research 67, 5275-84. PMID: 17545607 3. Annes, JP. et al. (2004) The Journal of cell biology 165, 723-34. PMID: 15184403 4. Wang, R. et al. (2012) Molecular biology of the cell 23, 1129-39. PMID: 22278742 5. Dong, X. et al. (2017) Nature 542, 55-59. PMID: 28117447
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human ITGB6 (SGN-B6A).

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Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO).pdf

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Anti-Human Integrin beta 6 Reference Antibody (SGN-B6A, RUO) (HB251016)

개요

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