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| 카탈로그 번호 | HX996016 |
|---|---|
| 설명 |
Anti-Human PRAME (GSK 2302032A) (HX996016) is a research-grade recombinant antibody targeting Opa-interacting protein 4. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | GSK 2302032A |
| 발현 시스템 | Mammalian cells |
| 성질 | Recombinant |
| 타겟 | Opa-interacting protein 4, Preferentially expressed antigen of melanoma, MAPE, OIP-4, Melanoma antigen preferentially expressed in tumors, PRAME, OIP4 |
| 내독소 수준 | < 10 EU/mg as determined by LAL method. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P78395 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | GSK-2302032A, GSK2302032A, GSK2302032A |
| 배경 | Melanoma antigen preferentially expressed in tumors (PRAME) is a ~57 kDa protein. Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation. Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. 1. Costessi, A. et al. (2011) The EMBO journal 30, 3786-98. PMID: 21822215 2. Lin, HC. et al. (2015) Science (New York, N.Y.) 349, 91-5. PMID: 26138980 3. Epping, MT. et al. (2005) Cell 122, 835-47. PMID: 16179254 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human PRAME (GSK 2302032A)
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