Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO) (HS929016)

Name: Anti-Human Nav1.7 Reference Antibody (Duke anti-Nav1.7, RUO)
Brand: abinScience
SKU: HS929016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HS929016
설명	Anti-Human SCN9A/Nav1.7 Antibody (Duke anti-NAv1.7) (HS929016) is a research-grade recombinant antibody targeting Sodium channel protein type 9 subunit alpha. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG
클론 ID	Duke anti-Nav1.7
발현 시스템	Mammalian cells
타겟	Sodium channel protein type 9 subunit alpha, NENA, Neuroendocrine sodium channel, Sodium channel protein type IX subunit alpha, SCN9A, Voltage-gated sodium channel subunit alpha Nav1.7, PN1, Peripheral sodium channel 1, hNE-Na
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q15858
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Sodium channel protein type 9 subunit alpha (SCN9A/Nav1.7) is a ~226 kDa protein. Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain. 1. Cummins, TR. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 8232-6. PMID: 15385606 2. Choi, JS. et al. (2006) Neurology 67, 1563-7. PMID: 16988069 3. Fertleman, CR. et al. (2006) Neuron 52, 767-74. PMID: 17145499 4. Cox, JJ. et al. (2006) Nature 444, 894-8. PMID: 17167479 5. Han, C. et al. (2009) Brain : a journal of neurology 132, 1711-22. PMID: 19369487 6. Eberhardt, M. et al. (2014) The Journal of biological chemistry 289, 1971-80. PMID: 24311784 7. Tan, ZY. et al. (2014) FEBS letters 588, 3964-9. PMID: 25240195 8. Ahuja, S. et al. (2015) Science (New York, N.Y.) 350, aac5464. PMID: 26680203 9. Klugbauer, N. et al. (1995) The EMBO journal 14, 1084-90. PMID: 7720699
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)