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| 카탈로그 번호 | HB274036 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG |
| 클론 ID | ST2485 |
| 생물학적 활성 | as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research [1]. |
| 발현 시스템 | Mammalian cells |
| 타겟 | Myotendinous antigen, Neuronectin, GMEM, Tenascin, Tenascin-C, TN-C, TNC, TN, Cytotactin, GP 150-225, Glioma-associated-extracellular matrix antigen, HXB, Hexabrachion, JI |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P24821 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | ST2485 |
| 배경 | Tenascin (Tenascin-C/TNC) is a ~240 kDa protein. Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells. 1. Martina, E. et al. (2010) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 24, 778-87. PMID: 19884327 |
| 참고 문헌 | 1. Petronzelli, F., et al., (2005). Improved tumor targeting by combined use of two antitenascin antibodies. Clinical cancer research: an official journal of the American Association for Cancer Research, 11(19 Pt 2), 7137s–7145s. [HB274036] |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-Human TNC (ST2485)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
