中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | VK623106 |
|---|---|
| 설명 |
Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Antibody (ADI-15878) (VK623106) is a research-grade recombinant antibody targeting Envelope glycoprotein. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Zaire ebolavirus (ZEBOV) (Zaire Ebola virus), Bundibugyo virus (BDBV), Sudan ebolavirus (SEBOV) (Sudan Ebola virus), Tai Forest ebolavirus (TAFV) (Cote d'Ivoire Ebola virus), Reston ebolavirus (REBOV) (Reston Ebola virus) |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1-kappa |
| 클론 ID | ADI-15878 |
| 타겟 | Envelope glycoprotein, GP, GP1, GP1,2, GP1,2-delta, GP2, Shed GP |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q05320 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Envelope glycoprotein (GP) is a ~74 kDa protein. Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, down-regulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity) (Probable). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. 1. Simmons, G. et al. (2002) Journal of virology 76, 2518-28. PMID: 11836430 2. Takada, A. et al. (2000) Virology 278, 20-6. PMID: 11112476 3. Iampietro, M. et al. (2017) PLoS pathogens 13, e1006397. PMID: 28542576 4. Edri, A. et al. (2018) Frontiers in immunology 9, 1428. PMID: 30013549 5. Vande Burgt, NH. et al. (2015) Viruses 7, 5587-602. PMID: 26516900 6. Brinkmann, C. et al. (2016) Journal of virology 90, 11075-11086. PMID: 27707924 7. González-Hernández, M. et al. (2018) Journal of virology 92. PMID: 29669839 8. Rizk, MG. et al. (2017) Journal of virology 91. PMID: 28878074 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
Research Grade Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Antibody (ADI-15878) (DVV03610)
SDS-PAGE for Anti-REBOV/SEBOV/TAFV/ZEBOV GP/Envelope glycoprotein Reference Antibody (ADI-15878, RUO)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
