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| 카탈로그 번호 | HW651016 | ||||||
|---|---|---|---|---|---|---|---|
| 설명 |
Ascrinvacumab (HW651016) is a research-grade recombinant antibody targeting Serine/threonine-protein kinase receptor R3. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 종 반응성 | Human | ||||||
| 응용 분야 | ELISA, WB, Bioactivity: FACS, Functional assay, Research in vivo | ||||||
| 숙주 종 | Human | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG2-kappa | ||||||
| 발현 시스템 | Mammalian cells | ||||||
| 테스트된 응용 분야 | WB | ||||||
| 타겟 | Serine/threonine-protein kinase receptor R3, ACVRL1, Activin receptor-like kinase 1, ALK-1, ACVRLK1, ALK1, SKR3, TGF-B superfamily receptor type I, TSR-I | ||||||
| 내독소 수준 | < 10 EU/mg | ||||||
| 순도 | >95% purity as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | P37023 | ||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 대체 이름 | PF-03446962, 1463459-96-2 | ||||||
| 배경 | Activin receptor type-1-like (ACVRL1/ALK-1) is a ~56 kDa protein. Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. | ||||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. | ||||||
| Isotype Control | Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107) |
SEC-HPLC detection for Research Grade Ascrinvacumab.
Detects ACVRL1/ALK-1 in indirect ELISAs.
SDS-PAGE for Anti-Human ALK-1 Reference Antibody (Ascrinvacumab, RUO)
Western blot analysis was performed using anti-ACVRL1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVRL1 (Catalog No: HW651011)
Lane 2: negative control
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