Anti-Canine beta-NGF Reference Antibody (Bedinvetmab, RUO) (CF909016)

Name: Anti-Canine beta-NGF Reference Antibody (Bedinvetmab, RUO)
Brand: abinScience
SKU: CF909016
Price: 176 USD
Availability: InStock

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가격(USD):

사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

수량:

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

CF909016

설명

Bedinvetmab (CF909016) is a research-grade recombinant antibody targeting NGF/Beta-NGF. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

종 반응성

Canine

응용 분야

ELISA, Bioactivity: FCM, Functional assay, Research in vivo

숙주 종

Canine

클론성

Monoclonal

이소타입

IgG2, lambda

타겟

Beta-NGF, Beta-nerve growth factor, NGF, NGFB

내독소 수준

< 10 EU/mg

순도

>95% as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

F1PDQ3

형태

Liquid

저장 완충액

0.01M PBS pH 7.4.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:2000-1:20000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

ZTS-00508841, 2171034-69-6

배경

Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.
• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244
• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273
• Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816
• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191
• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908
• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645
• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420
• β-NGF Stimulates Steroidogenic Enzyme and VEGFA Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615
• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046
• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111

참고사항

For research use only. Not suitable for clinical or therapeutic use.

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