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| 카탈로그 번호 | YP489016 | ||||
|---|---|---|---|---|---|
| 설명 |
Bentracimab (YP489016) is a research-grade recombinant antibody targeting Ticagrelor. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 종 반응성 | General | ||||
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | Fab-G1-lambda | ||||
| 클론 ID | Bentracimab | ||||
| 발현 시스템 | Mammalian cells | ||||
| 타겟 | Ticagrelor | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% purity as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | CAS: 274693-27-5 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 대체 이름 | MEDI2452, anti-ticagrelor, antidote for ticagrelor, CAS: 274693-27-5 | ||||
| 배경 | Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor. • Ticagrelor., PMID:35396017 • Ticagrelor with or without Aspirin in High-Risk Patients after PCI., PMID:31556978 • Ticagrelor or Clopidogrel Monotherapy vs Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Systematic Review and Patient-Level Meta-Analysis., PMID:38506796 • Ticagrelor: clinical development and future potential., PMID:34258905 • Ticagrelor resistance: a case series and algorithm for management of non-responders., PMID:34215660 • Is ticagrelor worth its high cost and side-effects?, PMID:29730968 • Ticagrelor in stable coronary disease., PMID:37586825 • Ticagrelor-Associated Urticaria., PMID:35639409 • Ticagrelor Use in Stroke Patients: Past, Present, and Future., PMID:34163168 • Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial., PMID:32334703 | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Bentracimab
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