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| 카탈로그 번호 | HY259056 |
|---|---|
| 설명 |
Anti-Human Fibronectin & IL-2 Bispecific Reference Antibody (Bifikafusp Alfa, RUO) (HY259056) targeting Fibronectin. Expressed in Mammalian cells.
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| 클론성 | Monoclonal |
| 이소타입 | scFv-heavy-kappa |
| 클론 ID | Bifikafusp Alfa |
| 생물학적 활성 | Fibronectin (FN) is a glycoprotein present in blood as well as in cells. While Fibronectin (FN) in blood has many functions, its primary role is to promote wound repair following injury [1]. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans (e.g. syndecans) [2]. |
| 발현 시스템 | Mammalian cells |
| 성질 | Recombinant |
| 타겟 | Cold-insoluble globulin, CIG, FN, Fibronectin, FN1, IL2, IL-2, Aldesleukin, Interleukin-2, TCGF, T-cell growth factor |
| 내독소 수준 | < 10 EU/mg as determined by LAL method. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Purified by Nickel column. |
| 등록번호 | P02751 & P60568 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | L19-IL-2, L19-IL2, L19IL2, 1957239-90-5 |
| 배경 | Bifikafusp alfa (L19-IL2) is an immunoresearch fusion protein consisting of human L19 antibodies fused to the human cytokine interleukin 2 (IL2).Bifikafusp alfa is specific to the EDB domain of fibronectin. Bifikafusp alfa has anticancer activity. |
| 참고 문헌 | 1. Yuan-Wan Sun, et al. Effects of E-Cigarette Aerosols with Varying Levels of Nicotine on Biomarkers of Oxidative Stress and Inflammation in Mice. Chem Res Toxicol. 2021 Apr 19;34(4):1161-1168. [HY259056] 2. Roumen Pankov, et al. Fibronectin at a glance. J Cell Sci. 2002 Oct 15;115(Pt 20):3861-3. [HY259056] |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Bifikafusp Alfa
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