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| 카탈로그 번호 | HC336186 | ||||
|---|---|---|---|---|---|
| 설명 |
Cinrebafusp alfa (HC336186) is a research-grade recombinant antibody targeting CD137. Produced in mammalian cells with native-like glycosylation.
Highlights
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, Bioactivity: FCM, Functional assay, Research in vivo, WB | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG | ||||
| 테스트된 응용 분야 | WB | ||||
| 타겟 | CD340, EC:2.7.10.1, ERBB2, HER2, MLN 19, MLN19, Metastatic lymph node gene 19 protein, NEU, NGL, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Receptor tyrosine-protein kinase erbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, 4-1BB ligand receptor, CD137, CDw137, ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9 | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P04626 & Q07011 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB; Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research. | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. | ||||
| Isotype Control | Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207) |
SDS-PAGE for Research Grade Cinrebafusp alfa.
Detects recombinant CD340 (Catalog No: HY286011) in indirect ELISA.
Detects recombinant CD137 (Catalog No: HC336011) in indirect ELISA.
Western blot analysis was performed using anti-CD137 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD137 (Catalog No: HC336011)
Lane 2: Negative control
Immunofluorescence staining of HDLM2 with Human monoclonal antibody (20ug/ml, overnight at 4°C), followed by Alexa Fluor-488-conjugated secondary antibody (6.5ug/ml, 50minutes at room temperature). The target protein was detected in the cell membrane.
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