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| 카탈로그 번호 | HX894016 |
|---|---|
| 설명 |
Daxdilimab (HX894016) is a research-grade recombinant antibody targeting CD85. Produced in mammalian cells with native-like glycosylation.
Highlights
|
| 종 반응성 | Human |
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG1-Lambda |
| 발현 시스템 | Mammalian cells |
| 타겟 | CD85g, ILT7, Immunoglobulin-like transcript 7, LILRA4, Leukocyte immunoglobulin-like receptor subfamily A member 4, ILT-7, CD85 antigen-like family member G |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% purity as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P59901 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | MEDI-7734, VIB-7734, 2245966-28-1 |
| 배경 | Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85g/LILRA4) is a ~55 kDa protein. Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. 1. Cao, W. et al. (2006) The Journal of experimental medicine 203, 1399-405. PMID: 16735691 2. Cao, W. et al. (2009) The Journal of experimental medicine 206, 1603-14. PMID: 19564354 3. Tavano, B. et al. (2014) PloS one 9, e89414. PMID: 24586760 4. Bego, MG. et al. (2015) PLoS pathogens 11, e1005024. PMID: 26172439 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107) |
SDS-PAGE for Research Grade Daxdilimab
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