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| 카탈로그 번호 | HB054016 | ||||
|---|---|---|---|---|---|
| 설명 |
Research Grade elfritatug (HB054016) is a human monoclonal antibody. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, Bioactivity: FACS, Functional assay, Research in vivo | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1, kappa | ||||
| 내독소 수준 | < 10 EU/mg | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P17693 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | HLA class I histocompatibility antigen, alpha chain G (HLA-G) is a ~38 kDa protein. Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface. In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins. Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance. Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. Through interaction with KIR2DL4 receptor on decidual macrophages induces pro-inflammatory cytokine production mainly associated with tissue remodeling. 1. Li, C. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 5767-72. PMID: 19304799 2. Rajagopalan, S. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20596-601. PMID: 23184984 3. Fu, B. et al. (2017) Immunity 47, 1100-1113.e6. PMID: 29262349 4. Lee, N. et al. (1995) Immunity 3, 591-600. PMID: 7584149 5. Diehl, M. et al. (1996) Current biology : CB 6, 305-14. PMID: 8805247 6. Rajagopalan, S. et al. (2006) PLoS biology 4, e9. PMID: 16366734 7. Gregori, S. et al. (2010) Blood 116, 935-44. PMID: 20448110 8. Köstlin, N. et al. (2017) European journal of immunology 47, 374-384. PMID: 27859042 9. Rajagopalan, S. et al. (1999) The Journal of experimental medicine 189, 1093-100. PMID: 10190900 | ||||
| 참고사항 | For research use only. |
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