Anti-SARS-CoV-2 RBD Reference Antibody (Ensovibep, RUO) (VK565336)

Name: Anti-SARS-CoV-2 RBD Reference Antibody (Ensovibep, RUO)
Brand: abinScience
SKU: VK565336
Price: 370 USD
Availability: InStock

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100ug
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개요

카탈로그 번호	VK565336
종 반응성	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
응용 분야	ELISA, Functional assay, Research in vivo
클론성	Monoclonal
이소타입	DARpin
생물학적 활성	BA 1 (0.1 uM) significantly increases FAK tyrosine phosphorylation in BRS-3 transfected NCI-H1299 cells [1].
성질	Recombinant
타겟	Spike glycoprotein, Spike, S glycoprotein, RBD
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Purified by Nickel column.
등록번호	P0DTC2
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	MP0420, D614Gvariant, B.1.351/Beta, P.1/Gamma, B.1.617.2/Delta, AY.2/DeltaPlus, AY.4.2/DeltaPlus, Lambda(C.37), Mu(B.1.621), Omicron(B.1.1.529, BA.1), Omicron(B.1.1.529, BA.2)
배경	Spike glycoprotein (RBD) is a ~141 kDa protein. Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. The major receptor is host ACE2. When S2/S2' has been cleaved, binding to the receptor triggers direct fusion at the cell membrane. When S2/S2' has not been cleaved, binding to the receptor results in internalization of the virus by endocytosis using host TFRC and GRM2 and leading to fusion of the virion membrane with the host endosomal membrane. Alternatively, may use NRP1/NRP2 and integrin as entry receptors. 1. Hoffmann, M. et al. (2020) Cell 181, 271-280.e8. PMID: 32142651 2. Walls, AC. et al. (2020) Cell 181, 281-292.e6. PMID: 32155444 3. Cao, W. et al. (2021) Biophysical journal 120, 1011-1019. PMID: 33607086 4. Takeda, M. (2022) Microbiology and immunology 66, 15-23. PMID: 34561887 5. Wrapp, D. et al. (2020) Science (New York, N.Y.) 367, 1260-1263. PMID: 32075877 6. Ou, X. et al. (2020) Nature communications 11, 1620. PMID: 32221306 7. Wang, J. et al. (2021) Cell discovery 7, 119. PMID: 34903715 8. Wang, X. et al. (2023) Journal of virology 97, e0161122. PMID: 36779763 9. Daly, JL. et al. (2020) Science (New York, N.Y.) 370, 861-865. PMID: 33082294 10. Cantuti-Castelvetri, L. et al. (2020) Science (New York, N.Y.) 370, 856-860. PMID: 33082293
참고 문헌	1. Terry W Moody, et al. ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Peptides. 2015 Feb;64:55-61. [VK565336]
참고사항	For research use only. Not suitable for clinical or therapeutic use.