Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO) (HS841016)

Name: Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO)
Brand: abinScience
SKU: HS841016
Price: 176 USD
Availability: InStock

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100ug
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개요
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참고 문헌
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SDS

개요

카탈로그 번호	HS841016
설명	Erenumab (HS841016) is a research-grade recombinant antibody targeting CGRP type 1 receptor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2-lambda
발현 시스템	Mammalian cells
타겟	CGRP type 1 receptor, CGRPR, Calcitonin receptor-like receptor, CALCRL, Calcitonin gene-related peptide type 1 receptor
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q16602
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	AMG334, erenumab-aooe, 1582205-90-0
배경	Calcitonin gene-related peptide type 1 receptor (CALCRL) is a ~52 kDa protein. G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Liang, YL. et al. (2020) ACS pharmacology & translational science 3, 263-284. PMID: 32296767 2. Josephs, TM. et al. (2021) Science (New York, N.Y.) 372. PMID: 33602864 3. Aiyar, N. et al. (1996) The Journal of biological chemistry 271, 11325-9. PMID: 8626685 4. McLatchie, LM. et al. (1998) Nature 393, 333-9. PMID: 9620797
참고사항	For research use only. Not suitable for clinical or therapeutic use.

이미지

Bioactivity

SEC-HPLC detection for Research Grade Erenumab.
SDS-PAGE

SDS-PAGE for Research Grade Erenumab

참고 문헌

데이터시트

Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO).pdf

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Formula

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어세이 키트

Anti-Human CRLR/CALCRL Reference Antibody (Erenumab, RUO) (HS841016)

개요

이미지

참고 문헌

데이터시트

SDS

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