Anti-Human IL-33 Reference Antibody (Itepekimab, RUO) (HF543026)

Name: Anti-Human IL-33 Reference Antibody (Itepekimab, RUO)
Brand: abinScience
SKU: HF543026
Price: 176 USD
Availability: InStock

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100ug
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개요

카탈로그 번호	HF543026
설명	Research Grade Itepekimab (HF543026) is a humanized monoclonal antibody detecting NF-HEV in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4-kappa
발현 시스템	Mammalian cells
종	Human
타겟	NF-HEV, IL-1F11, C9orf26, IL-33, Interleukin-1 family member 11, IL33, Nuclear factor from high endothelial venules, NFHEV, Interleukin-33, IL1F11
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	O95760
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	REGN-3500, SAR-440340, 2226742-52-3
배경	Interleukin-33 (NF-HEV,IL-1F11,C9orf26,IL-33,Interleukin-1 family member 11,IL33,Nuclear factor from high endothelial venules,NFHEV,Interleukin-33,IL1F11) is a ~30 kDa protein. Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. 1. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016 2. Kurowska-Stolarska, M. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 6469-77. PMID: 19841166 3. Komai-Koma, M. et al. (2007) European journal of immunology 37, 2779-86. PMID: 17853410 4. Moussion, C. et al. (2008) PloS one 3, e3331. PMID: 18836528
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4) (HP298207)