Anti-Human CD37 Reference Antibody (Ivicentamab, RUO) (HY564046)

Name: Anti-Human CD37 Reference Antibody (Ivicentamab, RUO)
Brand: abinScience
SKU: HY564046
Price: 176 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
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25mg
50mg
100mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HY564046
설명	Ivicentamab (HY564046) is a research-grade recombinant antibody targeting CD37. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-kappa
발현 시스템	Mammalian cells
테스트된 응용 분야	WB, FCM
타겟	CD37, Tspan-26, TSPAN26, Leukocyte antigen CD37, Tetraspanin-26
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P11049
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	DuoHexaBody-CD37, GEN3009, GEN-3009, GEN30092364496-42-2
배경	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Lapalombella, R. et al. (2012) Cancer cell 21, 694-708. PMID: 22624718 2. de Winde, CM. et al. (2016) The Journal of clinical investigation 126, 653-66. PMID: 26784544 3. Meyer-Wentrup, F. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 178, 154-62. PMID: 17182550
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

이미지

Bioactivity

SEC-HPLC detection for Research Grade Ivicentamab.
SDS-PAGE

SDS-PAGE for Research Grade Ivicentamab.
Flow CytoMetry

Flow-cytometry using APC anti-human CD37 antibody. Raji cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD37 monoclonal antibody (Catalog: HY564046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using FITC anti-human CD37 antibody. Raji cells were stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human CD37 monoclonal antibody (Catalog: HY564046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow CytoMetry

Flow-cytometry using PE anti-human CD37 antibody. Raji cells were stained with an irrelevant antibody (Blue Histogram) or an PE anti-human CD37 monoclonal antibody (Catalog: HY564046, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-CD37 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD37 (Catalog No: HY564012)
Lane 2: negative control
Bioactivity

Detects recombinant human CD37 (Catalog No: HY564012) in indirect ELISA