Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

Name: Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO)
Brand: abinScience
SKU: HF004206
Price: 400 USD
Availability: InStock

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개요

카탈로그 번호	HF004206
설명	Izalontamab (HF004206) is a research-grade recombinant antibody targeting HER1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-kappa-[scFv-heavy-lambda]2
테스트된 응용 분야	FCM
타겟	EC:2.7.10.1, EGFR, ERBB, ERBB1, Epidermal growth factor receptor, HER1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EC:2.7.10.1, ERBB3, HER3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P00533 & P21860
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	Tetravalentbispecific, SI-1, SI-1X6.4, SI-B001, 2559704-24-2
배경	Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects EGFR in indirect ELISA.
Flow cytometry

Flow-cytometry using anti-human ERBB3 antibody. HepG2 cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human ERBB3 monoclonal antibody (Catalog HF004206, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.

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Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO).pdf

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Anti-Human EGFR & ErbB3/Her3 Bispecific Reference Antibody (Izalontamab, RUO) (HF004206)

개요

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