Anti-Human Complement Component C5aR1 Reference Antibody (Izastobart, RUO) (HB064046)

Name: Anti-Human Complement Component C5aR1 Reference Antibody (Izastobart, RUO)
Brand: abinScience
SKU: HB064046
Price: 176 USD
Availability: InStock

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참고 문헌
데이터시트
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개요

카탈로그 번호	HB064046
설명	Izastobart (HB064046) is a research-grade recombinant antibody targeting CD88. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1-lambda
발현 시스템	Mammalian cells
타겟	CD88, C5AR1, C5R1, C5AR, C5a-R, C5aR, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P21730
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	2769937-42-8
배경	C5a anaphylatoxin chemotactic receptor 1 (CD88/C5AR1) is a ~39 kDa protein. Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. 1. Christophe, T. et al. (2000) The Journal of biological chemistry 275, 1656-64. PMID: 10636859 2. Postma, B. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 6994-7001. PMID: 15153520 3. Gerard, NP. et al. (1991) Nature 349, 614-7. PMID: 1847994 4. Robertson, N. et al. (2018) Nature 553, 111-114. PMID: 29300009 5. Feng, Y. et al. (2023) Cell research 33, 312-324. PMID: 36806352 6. Monk, PN. et al. (1995) The Journal of biological chemistry 270, 16625-9. PMID: 7622471 7. DeMartino, JA. et al. (1994) The Journal of biological chemistry 269, 14446-50. PMID: 8182049 8. Chen, Z. et al. (1998) The Journal of biological chemistry 273, 10411-9. PMID: 9553099 9. Yadav, MK. et al. (2023) Cell 186, 4956-4973.e21. PMID: 37852260
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)