Anti-Human RIA/ALK-2/Activin Receptor Type 1 Reference Antibody (Prafnosbart, RUO) (HC323016)

Name: Anti-Human RIA/ALK-2/Activin Receptor Type 1 Reference Antibody (Prafnosbart, RUO)
Brand: abinScience
SKU: HC323016
Price: 176 USD
Availability: InStock

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사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HC323016

설명

Prafnosbart (HC323016) is a research-grade recombinant antibody targeting SKR1. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

종 반응성

Human

응용 분야

ELISA, Bioactivity: FACS, Functional assay, Research in vivo, WB

숙주 종

Human

클론성

Monoclonal

이소타입

IgG1-kappa

발현 시스템

Mammalian cells

테스트된 응용 분야

타겟

SKR1, Activin receptor type-1, Activin receptor-like kinase 2, TSR-I, ACVRLK2, ACTR-I, ALK-2, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, ACVR1, Activin receptor type I

내독소 수준

< 10 EU/mg

순도

>95% purity as determined by SDS-PAGE.

정제

Protein A/G purified from cell culture supernatant.

등록번호

Q04771

형태

Liquid

저장 완충액

0.01M PBS pH 7.4

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

2566473-71-8

배경

Activin receptor type-1 (ACVR1/ALK-2) is a ~57 kDa protein. Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor.

1. Luo, J. et al. (2010) The Journal of biological chemistry 285, 29588-98. PMID: 20628059

2. Chaikuad, A. et al. (2012) The Journal of biological chemistry 287, 36990-8. PMID: 22977237

3. Renlund, N. et al. (2007) The Journal of endocrinology 195, 95-103. PMID: 17911401

4. Fujimoto, M. et al. (2015) Molecular endocrinology (Baltimore, Md.) 29, 140-52. PMID: 25354296

5. Macías-Silva, M. et al. (1998) The Journal of biological chemistry 273, 25628-36. PMID: 9748228

참고사항

For research use only. Not suitable for clinical or therapeutic use.

Isotype Control

Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

이미지

SDS-PAGE

SDS-PAGE for Research Grade Prafnosbart.
Western blot

Western blot analysis was performed using anti-ACVR1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human ACVR1 (Catalog No: HC323021)
Lane 2: Negative control