Anti-Human Clusterin Reference Antibody (Sotevtamab, RUO) (HY453016)

Name: Anti-Human Clusterin Reference Antibody (Sotevtamab, RUO)
Brand: abinScience
SKU: HY453016
Price: 176 USD
Availability: InStock

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개요

카탈로그 번호	HY453016
설명	Sotevtamab (HY453016) is a research-grade recombinant antibody targeting APOJ. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2-kappa
발현 시스템	Mammalian cells
성질	Recombinant
타겟	APOJ, ApoJalpha, NA1/NA2, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Ku70-binding protein 1, Testosterone-repressed prostate message 2, ApoJbeta, TRPM-2, Complement cytolysis inhibitor b chain, SGP-2, KUB1, Apolipoprotein J, Apo-J, Clusterin, Sulfated glycoprotein 2, Aging-associated gene 4 protein, CLI, CLU, Complement-associated protein SP-40, 40
내독소 수준	< 10 EU/mg as determined by LAL method.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P10909
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	16B5, AB-16B52411526-47-9
배경	Clusterin (APOJ/SP-40) is a ~52 kDa protein. Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. 1. Poon, S. et al. (2000) Biochemistry 39, 15953-60. PMID: 11123922 2. Wyatt, AR. et al. (2009) The Journal of biological chemistry 284, 21920-21927. PMID: 19535339 3. Poon, S. et al. (2002) The Journal of biological chemistry 277, 39532-40. PMID: 12176985 4. Stewart, EM. et al. (2007) Biochemistry 46, 1412-22. PMID: 17260971 5. Wyatt, AR. et al. (2010) The Journal of biological chemistry 285, 3532-3539. PMID: 19996109 6. Hatters, DM. et al. (2002) European journal of biochemistry 269, 2789-94. PMID: 12047389 7. Kumita, JR. et al. (2007) Journal of molecular biology 369, 157-67. PMID: 17407782 8. Yerbury, JJ. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2312-22. PMID: 17412999
참고사항	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human Clusterin Reference Antibody (Sotevtamab, RUO).pdf

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Anti-Human Clusterin Reference Antibody (Sotevtamab, RUO) (HY453016)

개요

이미지

참고 문헌

데이터시트

SDS