Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO) (HW444066)

Name: Anti-Human CCR8 Reference Antibody (Tagmokitug, RUO)
Brand: abinScience
SKU: HW444066
Price: 176 USD
Availability: InStock

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100ug
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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HW444066
설명	tagmokitug (HW444066) is a research-grade recombinant antibody targeting CD198. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research.
종 반응성	Human
응용 분야	ELISA, FACS, Functional assay
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, lambda2
타겟	CD198/CCR8
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE
정제	Protein A/G purified from cell culture supernatant.
등록번호	P51685
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CAS: 3024486-14-1
배경	C-C chemokine receptor type 8 is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
참고사항	For research use only.