Research Grade Timdarpacept (HX892106)

Name: Research Grade Timdarpacept
Brand: abinScience
SKU: HX892106
Price: 192 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HX892106
설명	Timdarpacept (HX892106) is a research-grade recombinant antibody targeting CD172. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Functional assay, Research in vivo
클론성	Monoclonal
이소타입	Fusion-[human signal-regulatory protein alpha (SIRPα) receptor domain 1 fragment (1-133) natural variant V2 (SIRPα V2)]2-IgG1-Fc (Fragment constant)
타겟	BIT, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Purified by Nickel column.
등록번호	P78324
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	2749520-17-8
배경	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
참고사항	For research use only. Not suitable for clinical or therapeutic use.