Anti-Human BTLA/CD272 Reference Antibody (Venanprubart, RUO) (HV375056)

Name: Anti-Human BTLA/CD272 Reference Antibody (Venanprubart, RUO)
Brand: abinScience
SKU: HV375056
Price: 176 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HV375056
설명	Venanprubart (HV375056) is a research-grade recombinant antibody targeting CD272. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4-kappa
발현 시스템	Mammalian cells
타겟	B- and T-lymphocyte attenuator, BTLA, CD272, B- and T-lymphocyte-associated protein
내독소 수준	< 10 EU/mg
순도	>95% purity as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q7Z6A9
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	2635407-50-8
배경	B- and T-lymphocyte attenuator (CD272/BTLA) is a ~32 kDa protein. Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. 1. Watanabe, N. et al. (2003) Nature immunology 4, 670-9. PMID: 12796776 2. Gavrieli, M. et al. (2003) Biochemical and biophysical research communications 312, 1236-43. PMID: 14652006 3. Sedy, JR. et al. (2005) Nature immunology 6, 90-8. PMID: 15568026 4. Cai, G. et al. (2008) Nature immunology 9, 176-85. PMID: 18193050 5. Cheung, TC. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 183, 7286-96. PMID: 19915044
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG4 (S228P) Recombinant Isotype Control Antibody (SAA0184) (HP298107)

이미지

SDS-PAGE

SDS-PAGE for Research Grade Venanprubart.
Flow cytometry

Flow-cytometry APC using anti-human CD272 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an APC anti-human CD272 monoclonal antibody (Catalog HV375056) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry PE using anti-human CD272 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an PE anti-human CD272 monoclonal antibody (Catalog HV375056) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Flow cytometry

Flow-cytometry FITC using anti-human CD272 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an FITC anti-human CD272 monoclonal antibody (Catalog HV375056) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.