Pseudorabies Virus (PRV/SuHV-1) Research Reagents — Antibodies & Recombinant Proteins

Glycoprotein D (gD/US6) — Receptor Binding
gD binds nectin-1 to trigger viral entry and is the primary PRV vaccine immunogen. Available: recombinant gD proteins — C-His (VK437011) and N-His (VK437012); and anti-gD polyclonal antibody (VK437014).

Glycoprotein B (gB/UL27) — Class III Fusogen
gB is the conserved herpesvirus fusion protein essential for membrane fusion. abinScience provides the deepest anti-PRV gB reagent set: InVivoMAb neutralizing antibodies Iv (VK597010) and Iv (VK597020); recombinant gB proteins — C-His (VK597011), C-His (VK049011), and N-His (VK049012); and anti-gB polyclonal antibody (VK049014).

Glycoprotein H/gL — Fusion Trigger Complex
gH/gL heterodimer triggers gB conformational change for membrane fusion. Available: InVivoMAb anti-gH D6.3 (VK485010); gH recombinant proteins — C-His (VK047011) and N-His (VK047012); anti-gH pAb (VK047014); and gL recombinant protein C-Strep (VK048011).

Glycoprotein E (gE) — DIVA Serology Antigen
gE is deleted in all major PRV marker vaccines (Bartha, Begonia, NIA-3 gE⁻) used in eradication programs worldwide. Detection of anti-gE antibodies differentiates field-infected animals from vaccinated animals (DIVA principle). gE recombinant protein is the standard ELISA coating antigen for DIVA serology. Available: gE C-Strep (VK711011), gE N-His-SUMO (VK711012), and anti-gE polyclonal antibody (VK711014).

Glycoprotein C (gC) & Glycoprotein M (gM)
gC binds complement C3b and heparan sulfate, mediating complement evasion and initial cell attachment. gM is essential for virion envelopment and egress. Available:
• gC: N-His-KSI (VK051012) and anti-gC pAb (VK051014)
• gM: N-His-KSI (VK050012) and anti-gM pAb (VK050014)

UL42 (polymerase accessory protein/PAP) is the DNA polymerase processivity factor essential for viral DNA replication. UL42 is a validated antiviral drug target — disrupting UL42–polymerase interaction blocks viral replication. abinScience offers the deepest anti-UL42 antibody panel available for any herpesvirus:

6 Recombinant Antibody Clones
2G11 (VK649013), 7C11 (VK649023), 8F9 (VK649033), 5F8 (VK649043), 2D5 (VK649053), and 4E2# (VK649063) — enabling epitope mapping, functional blocking studies, and competition binning of the UL42-polymerase interaction interface.

UL42 Proteins & Polyclonal Antibodies
Domain-specific recombinant proteins: UL42 (1-148) N-His (VK649012) and UL42 (256-384) N-His (VK649022); polyclonal antibodies VK649014 and VK649024.

Which reagents are needed for PRV DIVA serology?
DIVA (Differentiating Infected from Vaccinated Animals) relies on detecting anti-gE antibodies — present in field-infected pigs but absent in animals vaccinated with gE-deleted marker vaccines (Bartha, etc.). Use gE C-Strep (VK711011) or gE N-His-SUMO (VK711012) as ELISA coating antigen, with anti-gE pAb (VK711014) as positive control.

Which antibodies are recommended for PRV neutralization studies?
For gB-mediated fusion blockade: InVivoMAb antibodies VK597010 and VK597020. For gH-mediated fusion triggering: InVivoMAb D6.3 (VK485010). Combining anti-gB + anti-gH provides synergistic neutralization. All InVivoMAb antibodies are produced low-endotoxin, azide-free for in vivo use.

Can PRV reagents be used for neural circuit tracing research?
Yes. PRV (particularly the Bartha strain) is the gold-standard retrograde transynaptic tracer for mapping neural circuits. Our gB, gD, gH, and gE antibodies can be used to detect PRV-infected neurons by IHC and immunofluorescence in brain tissue sections, confirm viral spread directionality, and characterize recombinant PRV tracer variants.

Why do you have 6 antibody clones against UL42?
UL42/PAP is an attractive antiviral target — small molecules that disrupt the UL42-polymerase interaction can block viral DNA replication. Having 6 clones targeting different epitopes enables detailed mapping of the UL42-polymerase binding interface, competition assays for drug screening, and identification of functional domains critical for processivity factor activity.

Explore reagents for related viruses:

PRV / SuHV-1 ✓ HSV-1 VZV PRRSV CSFV ASFV PEDV