Varicella-Zoster Virus (VZV/HHV-3) Research Reagents — Antibodies & Recombinant Proteins

Glycoprotein E (gE/ORF68)
gE is the most abundant VZV envelope glycoprotein and the key immunogen in the recombinant zoster vaccine Shingrix (GSK). gE is essential for cell-to-cell spread and forms a heterodimer with gI for Fc receptor-mediated immune evasion. Available reagents:
• Monoclonal antibodies: clones 1A139 (VK561045), 1A140 (VK561055), and 1A141 (VK561065)
• Recombinant proteins: gE C-His (VK561011), gE N-His (VK561012), gE N-His variant (VK561022)
• Anti-gE polyclonal antibody (VK561014)

Glycoprotein H / gH-gL Complex
The gH/gL heterodimer is essential for membrane fusion during VZV entry and cell-to-cell spread. gH/gL is a target for broadly neutralizing antibodies and a promising vaccine candidate beyond gE. Available reagents:
• InVivoMAb antibodies for in vivo studies: anti-gH/gL clones Iv0041 (VK724010) and Iv0042 (VK724020), anti-gH clone mab (VK743010)
• Recombinant proteins: gH&gL complex C-Strep&C-His (VK724011), gH C-Strep (VK743011), gH N-His (VK743012)
• Anti-gH polyclonal antibody (VK743014)

Glycoprotein I (gI)
gI forms a heterodimer with gE and is required for efficient cell-to-cell spread and Fc receptor-mediated immune evasion. Available reagents: recombinant gI proteins in three formats — C-Strep (VK097011), N-GST&C-His (VK097012), N-His (VK097022) — and polyclonal antibodies VK097014 and VK097024.

Glycoprotein B (gB)
gB is a class III fusion protein conserved across all herpesviruses, essential for membrane fusion during viral entry. Available: InVivoMAb anti-gB Iv0043 (VK398010) for in vivo neutralization studies, recombinant gB protein N-His (VK398012), and anti-gB polyclonal antibody (VK398014).

Glycoprotein L (gL) & Accessory Proteins
gL is the light chain of the gH/gL fusion complex. abinScience also provides the viral assemblin protease for VZV capsid maturation studies. Available: gL recombinant proteins (C-His VK410011, N-His VK410012), anti-gL pAb (VK410014), assemblin protein (VK148012), and anti-assemblin pAb (VK148014).

Which antibodies are suitable for VZV neutralization studies?
For in vivo neutralization, we offer four InVivoMAb antibodies: anti-gH/gL clones Iv0041 and Iv0042 targeting the fusion complex, anti-gH VK743010, and anti-gB Iv0043. All are produced under low-endotoxin, azide-free conditions for animal studies.

Which gE protein should I use for Shingrix-related vaccine research?
Shingrix uses truncated VZV gE (ectodomain) as immunogen. Our gE C-His (VK561011) is a recombinant ectodomain suitable for use as a reference antigen in ELISA-based immunogenicity studies, serology assay development, and antibody screening.

Do you have matched antibody-antigen pairs for VZV serology assays?
Yes. For gE-based serology: pair gE protein (VK561011) as coating antigen with anti-gE monoclonal clones (1A139, 1A140, 1A141) for competition ELISA or as positive controls. Contact us for pair optimization support.

Explore reagents for related herpesviruses:

HSV-1 (HHV-1) HSV-2 (HHV-2) VZV (HHV-3) ✓ EBV (HHV-4) CMV (HHV-5) Pseudorabies (PRV)