Classical Swine Fever Virus (CSFV) Research Reagents — Antibodies & Recombinant Proteins

Classical swine fever (CSF) is a highly contagious viral disease caused by CSFV, a pestivirus in the family Flaviviridae. The virus affects domestic and wild pigs globally, with significant economic impact. CSFV encodes three structural proteins—E1 and E2 envelope glycoproteins, and capsid protein C—plus several non-structural proteins (NS5A, NS5B, NS4, p7) essential for viral replication. E1 and E2 are primary vaccine targets; NS proteins serve as diagnostic markers and antiviral research targets.

Research Use Only (RUO)Not intended for diagnostic or therapeutic procedures.

CSFV virion structure — E1/E2 glycoproteins and capsid

Fig. 1 CSFV structure. E1/E2 envelope glycoproteins mediate cell entry; capsid protein encapsidates genome.

abinScience provides monoclonal and polyclonal antibodies and recombinant antigens for CSFV research. All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems. Contact us for assay development support.

Key Research Targets

Envelope Glycoprotein E1 (gp33) — Primary neutralizing antigen and vaccine target. E1-specific monoclonal and polyclonal antibodies (VK529015, VK529025) support neutralization assays and vaccine immunogenicity studies.
→ Browse CSFV E1 products

Envelope Glycoprotein E2 (gp55) — Structural glycoprotein supporting immune recognition. Anti-E2 monoclonal antibodies (VK750013, VK750023) and recombinant E2 proteins (VK750011, VK750021, VK750031) enable epitope mapping and sandwich ELISA development.
→ Browse CSFV E2 products

Non-Structural Proteins (NS5A, NS5B, NS4, p7) — Essential for viral replication and assembly. NS-specific monoclonal and polyclonal antibodies enable viral replication monitoring and diagnostic assay development. Recombinant NS proteins (VK463012, VK463022, VK803012, VK803022, VK687011) serve as assay standards and immunogens.
→ Browse all CSFV products

Recommended Applications

Serological Diagnosis
CSFV E1 and E2 recombinant antigens are optimal ELISA coating antigens. Matched monoclonal antibody pairs (capture/detection) enable rapid serodetection for acute and convalescent CSF cases in outbreak investigations.

Vaccine Development & Viral Replication Studies
E1-specific neutralizing antibodies quantify vaccine-induced protection. NS protein detection monitors active viral replication. Recombinant E1, E2, and NS proteins serve as immunogens and assay standards for vaccine potency testing.

References

1. Moennig V, Floegel-Niesmann G, Greiser-Wilke I. Clinical signs and epidemiology of classical swine fever: a review of new knowledge. Vet J. 2003;165(1):11-20.

2. Blome S, Gabriel C, Beer M. Swine fever—from past to present. Curr Top Microbiol Immunol. 2013;369:1-28.

3. Tautz N, Tews BA, Meyers G. The molecular biology of pestiviruses. Adv Virus Res. 2015;93:47-160.

4. Ruggli N, Tratschin JD, Mittelholzer C, et al. Classical swine fever virus glycoprotein E1 is not obligatory for viral replication in cell culture. J Virol. 2002;76(14):7088-7095.

All products manufactured by AtaGenix Laboratories under ISO 9001 & ISO 13485 quality systems. Contact us for custom antibody development.