Porcine Deltacoronavirus (PDCoV) Research Reagents — Antibodies & Recombinant Proteins

Spike Protein (S / S1-NTD / S1-CTD)
The spike glycoprotein mediates receptor binding (APN/CD13) and membrane fusion. S1-NTD and S1-CTD/RBD contain distinct neutralizing epitopes. abinScience offers the deepest PDCoV spike panel available:
• Full-length spike: S C-His (VK682031)
• S1-NTD: C-Fc (VK682011), C-His (VK682021), N-His (VK682012), and anti-S1-NTD pAb (VK682014)
• S1-CTD/RBD: N-His (VK682022) and anti-S1-CTD pAb (VK682024)
• Anti-Spike recombinant antibodies: SAA2563 (VK682013) and SAA2564 (VK682023) targeting RBD, and SAA2565 (VK682033) targeting S1-NTD

Nucleocapsid (N)
N is the most abundant viral protein and the standard diagnostic antigen for PDCoV serological assays and antigen-capture ELISAs. Available: recombinant N protein N-His (VK771012) and anti-N polyclonal antibody (VK771014).

Membrane Protein (M)
M is the most abundant envelope protein and participates in virion assembly and budding. Available: recombinant M protein N-His (VK779012) and anti-M polyclonal antibody (VK779014).

abinScience provides the most extensive PDCoV non-structural protein panel available — covering 8 NSPs and 1 accessory protein, each paired with a polyclonal detection antibody:

NSP5/Mpro/3CL Protease — Main Drug Target
The 3CL protease cleaves the replicase polyprotein and is structurally homologous to SARS-CoV-2 Mpro. Available: protein N-His (VK537012) and anti-3CL pAb (VK537014).

NSP3/PLpro — Papain-Like Protease
PLpro cleaves the N-terminal polyprotein and has deubiquitinating/deISGylating activity to suppress innate immunity. Available: protein N-His (VK537022) and anti-PLpro pAb (VK537024).

Replication Complex Components
• NSP7: primase cofactor — protein N-GST&C-His (VK537032), protein N-His (VK537092), pAb (VK537034), pAb (VK537094)
• NSP8: primase — protein N-His (VK537042) and pAb (VK537044)
• NSP9: ssRNA-binding protein — protein N-GST&C-His (VK537052) and pAb (VK537054)
• NSP10/GFL: methyltransferase cofactor — protein N-His (VK537062) and pAb (VK537064)
• NSP13: helicase — protein N-His (VK537072) and pAb (VK537074)
• NSP2: pAb (VK537084)

NS6 — Accessory Protein
NS6 is the only characterized PDCoV accessory protein, with IFN antagonist function. Available: protein N-GST&C-His (VK650012) and anti-NS6 pAb (VK650014).

Why is PDCoV considered a pandemic preparedness concern?
PDCoV was detected in Haitian children with febrile illness in 2021, confirming zoonotic transmission to humans. PDCoV uses aminopeptidase N (APN/CD13) as its receptor — APN is conserved across mammals (pigs, humans, cats, chickens), giving PDCoV exceptionally broad host range among coronaviruses. This cross-species capability, combined with its enteric tropism and potential for rapid evolution, places PDCoV on pandemic preparedness surveillance lists.

Can PDCoV NSPs be used for pan-coronavirus antiviral screening?
Yes. PDCoV 3CL protease (NSP5/Mpro) and PLpro (NSP3) are structurally homologous to their SARS-CoV-2 counterparts. Our PDCoV NSP panel enables comparative inhibitor profiling across coronavirus genera — deltacoronavirus (PDCoV), betacoronavirus (SARS-CoV-2, MHV), and gammacoronavirus (IBV) — critical for identifying broad-spectrum coronavirus antivirals.

How do I differentiate PDCoV from PEDV and TGEV in diagnostic assays?
Use N protein-based ELISA — PDCoV N (VK771012) shows minimal cross-reactivity with PEDV and TGEV N proteins. For spike-based differentiation: anti-S1-NTD antibodies are genus-specific (deltacoronavirus S1-NTD has no structural homology to alpha/betacoronavirus S1). Pair with our PEDV reagents for multiplex swine enteric coronavirus panels.

Explore reagents for related coronaviruses and swine viruses:

PDCoV ✓ PEDV SARS-CoV-2 MHV IBV PRRSV CSFV ASFV