Animal Dander Allergen Research Reagents

Fel d 1 (Cat) — A secretoglobin heterodimer produced primarily in cat sebaceous and salivary glands. Fel d 1 is the dominant cat allergen, responsible for >90% of cat-specific IgE reactivity. Its exceptional aerodynamic properties (carried on small particles <5 μm) enable deep lung penetration and persistent environmental contamination. Anti-Fel d 1 monoclonal antibodies are in development for passive immunotherapy and allergen-neutralizing approaches.
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Can f 1 / Can f 2 / Can f 5 (Dog) — Can f 1 (lipocalin) and Can f 2 (lipocalin) are the major dog dander allergens. Can f 5 (arginine esterase/prostatic kallikrein) is uniquely produced by male dogs and cross-reacts with human PSA, explaining why some patients tolerate female but not male dogs. CRD with Can f 5 enables gender-specific avoidance counseling.
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Equ c 1 (Horse) — The major horse allergen (lipocalin), responsible for severe allergic reactions including anaphylaxis upon direct horse exposure. Equ c 1 cross-reacts with other lipocalin allergens (Can f 1, Fel d 4), contributing to multi-pet sensitization patterns.
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