Anti-CCND1 Polyclonal Antibody (HB241014)

Name: Anti-CCND1 Polyclonal Antibody
Brand: abinScience
SKU: HB241014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

HB241014

설명

Anti-CCND1 Polyclonal Antibody (HB241014) is a rabbit polyclonal antibody detecting CCND1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CCND1 (Glu66-Arg245).

타겟

B-cell lymphoma 1 protein, G1/S-specific cyclin-D1, BCL1, PRAD1, CCND1, PRAD1 oncogene, BCL-1 oncogene, BCL-1

정제

Purified by antigen affinity column.

등록번호

P24385

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

G1/S-specific cyclin-D1 (CCND1) is a ~33 kDa protein. Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity.

1. Xiong, Y. et al. (1991) Cell 65, 691-9. PMID: 1827756

2. Lew, DJ. et al. (1991) Cell 66, 1197-206. PMID: 1833066

3. Santra, MK. et al. (2009) Nature 459, 722-5. PMID: 19412162

4. Simoneschi, D. et al. (2021) Nature 592, 789-793. PMID: 33854235

5. Meyerson, M. et al. (1994) Molecular and cellular biology 14, 2077-86. PMID: 8114739

6. Bates, S. et al. (1994) Oncogene 9, 71-9. PMID: 8302605

8. LaBaer, J. et al. (1997) Genes & development 11, 847-62. PMID: 9106657

참고사항

For research use only.

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