Anti-CD156c/ADAM10 Polyclonal Antibody (HT182014)

Name: Anti-CD156c/ADAM10 Polyclonal Antibody
Brand: abinScience
SKU: HT182014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HT182014

설명

Anti-CD156c/ADAM10 Polyclonal Antibody (HT182014) is a rabbit polyclonal antibody detecting CD156c in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Pig.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD156c/ADAM10 (Thr214-Ser504).

타겟

ADAM 10, Mammalian disintegrin-metalloprotease, CD156c, MADM, ADAM10, Kuzbanian protein homolog, KUZ, CDw156, Disintegrin and metalloproteinase domain-containing protein 10

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O14672

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Disintegrin and metalloproteinase domain-containing protein 10 (CD156c/ADAM10) is a ~84 kDa protein. Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP).

1. Lemjabbar, H. et al. (2002) Nature medicine 8, 41-6. PMID: 11786905

2. Gutwein, P. et al. (2003) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 17, 292-4. PMID: 12475894

3. Rabquer, BJ. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 185, 1777-85. PMID: 20592283

4. Kleinberger, G. et al. (2014) Science translational medicine 6, 243ra86. PMID: 24990881

5. Jouannet, S. et al. (2016) Cellular and molecular life sciences : CMLS 73, 1895-915. PMID: 26686862

6. Reyat, JS. et al. (2017) Journal of immunology (Baltimore, Md. : 1950) 199, 666-676. PMID: 28600292

7. Eschenbrenner, E. et al. (2020) Life science alliance 3. PMID: 31792032

8. Lipper, CH. et al. (2022) Structure (London, England : 1993) 30, 206-214.e4. PMID: 34739841

9. Lipper, CH. et al. (2023) Cell 186, 3632-3641.e10. PMID: 37516108

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CD156c/ADAM10 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CD156c/ADAM10 Polyclonal Antibody (HT182014)

개요

이미지

참고 문헌

데이터시트

SDS

빠른 접근

문의하기