Anti-Human MDR1/ABCB1 Polyclonal Antibody (HY466014)

Name: Anti-Human MDR1/ABCB1 Polyclonal Antibody
Brand: abinScience
SKU: HY466014
Price: 168 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HY466014

설명

Anti-Human MDR1/ABCB1 Polyclonal Antibody (HY466014) is a rabbit polyclonal antibody detecting MDR1/ABCB1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CD243/ABCB1 (Phe394-Val672).

타겟

Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1

정제

Purified by antigen affinity column.

등록번호

P08183

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

ATP-dependent translocase ABCB1 (CD243) is a ~141 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

1. Choi, KH. et al. (1988) Cell 53, 519-29. PMID: 2897240

2. Masud, SN. et al. (2022) Nature chemical biology 18, 1370-1379. PMID: 35970996

3. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203

4. Chen, G. et al. (1997) The Journal of biological chemistry 272, 5974-82. PMID: 9038218

5. Shafik, SH. et al. (2022) PLoS biology 20, e3001616. PMID: 35507548

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human MDR1/ABCB1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MDR1/ABCB1 Polyclonal Antibody (HY466014)

개요

이미지

참고 문헌

데이터시트

SDS