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| 카탈로그 번호 | HX237014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-CD83 Polyclonal Antibody (HX237014) is a rabbit polyclonal antibody detecting CD83 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human CD83 (Lys24-Val205). | ||||||||
| 타겟 | CD83, hCD83, CD83 antigen, B-cell activation protein, Cell surface protein HB15 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q01151 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | CD83 antigen is a ~23 kDa protein. Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation. In addition, acts as an important modulator of protective responses against acute infections. 1. Tze, LE. et al. (2011) The Journal of experimental medicine 208, 149-65. PMID: 21220452 | ||||||||
| 참고사항 | For research use only. |
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