Anti-CYP21A2 Polyclonal Antibody (HY097014)

Name: Anti-CYP21A2 Polyclonal Antibody
Brand: abinScience
SKU: HY097014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HY097014

설명

Anti-CYP21A2 Polyclonal Antibody (HY097014) is a rabbit polyclonal antibody detecting CYP21A2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CYP21A2 (Leu107-Gly390).

타겟

CYP21, CYP21B, Cytochrome P450 21, Cytochrome P450-C21B, Cytochrome P450-C21, Cytochrome P450 XXI, 21-OHase, Steroid 21-hydroxylase, Cytochrome P-450c21, CYP21A2

정제

Purified by antigen affinity column.

등록번호

P08686

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Steroid 21-hydroxylase (CYP21A2) is a ~56 kDa protein. A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).

1. Tajima, T. et al. (1999) Gene therapy 6, 1898-903. PMID: 10602386

2. Grischuk, Y. et al. (2006) The Journal of clinical endocrinology and metabolism 91, 4976-80. PMID: 16984992

3. Concolino, P. et al. (2012) Metabolism: clinical and experimental 61, 519-24. PMID: 22014889

4. Pallan, PS. et al. (2015) The Journal of biological chemistry 290, 13128-43. PMID: 25855791

5. de Paula Michelatto, D. et al. (2016) International journal of endocrinology 2016, 4209670. PMID: 27721825

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-CYP21A2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-CYP21A2 Polyclonal Antibody (HY097014)

개요

이미지

참고 문헌

데이터시트

SDS