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| 카탈로그 번호 | HC114013 |
|---|---|
| 설명 |
Anti-G protein Nanobody (Nb35) [Nb35] (HC114013) is a alpaca monoclonal antibody detecting G protein in Cyro-EM, X-ray Crystallography. Suitable for Human.
|
| 종 반응성 | Human |
| 응용 분야 | Cyro-EM, X-ray Crystallography |
| 숙주 종 | Alpaca |
| 클론성 | Monoclonal |
| 이소타입 | VHH-His |
| 클론 ID | Nb35 |
| 타겟 | G protein |
| 내독소 수준 | <0.01 EU/ug |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Purified by Nickel column. |
| 등록번호 | P63092 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | Nanobody 35, Nanobody-35, Nb-35 |
| 배경 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short is a ~45 kDa protein. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. 1. Pak, Y. et al. (2002) Molecular and cellular biology 22, 7942-52. PMID: 12391161 2. Gao, X. et al. (2007) The Journal of biological chemistry 282, 294-302. PMID: 17110384 3. Thiele, S. et al. (2011) Human mutation 32, 653-60. PMID: 21488135 4. Brand, CS. et al. (2015) Molecular pharmacology 88, 758-67. PMID: 26206488 5. Farfel, Z. et al. (1996) The Journal of biological chemistry 271, 19653-5. PMID: 8702665 6. Warner, DR. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 4268-72. PMID: 10200251 |
| 참고사항 | For research use only |
SDS-PAGE for Anti-G protein Nanobody (Nb35)
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