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| 카탈로그 번호 | HB264014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-GRN Polyclonal Antibody (HB264014) is a rabbit polyclonal antibody detecting GRN in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human GRN (Thr18-Asp363). | ||||||||
| 타겟 | PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P28799 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. 1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812 2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771 3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925 4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791 5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286 | ||||||||
| 참고사항 | For research use only. |
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