Anti-HSPA9 Polyclonal Antibody (HW569014)

Name: Anti-HSPA9 Polyclonal Antibody
Brand: abinScience
SKU: HW569014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HW569014

설명

Anti-HSPA9 Polyclonal Antibody (HW569014) is a rabbit polyclonal antibody detecting HSPA9 in ELISA, IHC, WB. Suitable for Bovine, Dog, Cricetulus griseus, Chicken, and Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human HSPA9 (Ser65-Ala311).

타겟

mt-HSP70, HSPA9B, MOT, Peptide-binding protein 74, Stress-70 protein, mitochondrial, PBP74, GRP-75, Mortalin, Heat shock 70 kDa protein 9, GRP75, 75 kDa glucose-regulated protein, HSPA9

정제

Purified by antigen affinity column.

등록번호

P38646

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Stress-70 protein, mitochondrial (HSPA9/Mortalin) is a ~73 kDa protein. Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones. In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins. Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU.

1. Zhai, P. et al. (2008) The Journal of biological chemistry 283, 26098-106. PMID: 18632665

2. Dores-Silva, PR. et al. (2015) PloS one 10, e0117170. PMID: 25615450

3. Srivastava, S. et al. (2017) The Journal of biological chemistry 292, 18075-18090. PMID: 28848044

4. Moseng, MA. et al. (2019) The journal of physical chemistry. B 123, 3383-3396. PMID: 30933555

5. Moseng, MA. et al. (2019) FEBS letters 593, 2030-2039. PMID: 31177526

6. Shan, Y. et al. (2016) Mitochondrion 26, 94-103. PMID: 26702583

7. Chen, TH. et al. (2011) Blood 117, 1530-9. PMID: 21123823

8. Sane, S. et al. (2014) Cell death & disease 5, e1118. PMID: 24625977

9. Sane, S. et al. (2016) Cell stress & chaperones 21, 313-26. PMID: 26634371

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-HSPA9 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-HSPA9 Polyclonal Antibody (HW569014)

개요

이미지

참고 문헌

데이터시트

SDS

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