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| 카탈로그 번호 | VK044014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-HTLV-1 Tax Polyclonal Antibody (VK044014) is a rabbit polyclonal antibody detecting Protein Tax-1 in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Human T-cell leukemia virus 1 (HTLV-1) | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant HTLV-1 Tax (Gly26-Pro224). | ||||||||
| 타겟 | Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1, Tax | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P03409 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Protein Tax-1 is a ~39 kDa protein. Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B. 1. Kusano, S. et al. (2012) Virology 432, 343-52. PMID: 22789739 2. Tie, F. et al. (1996) Journal of virology 70, 8368-74. PMID: 8970957 3. Groussaud, D. et al. (2017) PLoS pathogens 13, e1006518. PMID: 28742148 4. Wang, C. et al. (2016) PLoS pathogens 12, e1005584. PMID: 27082114 5. Shibata, Y. et al. (2017) PLoS pathogens 13, e1006162. PMID: 28103322 | ||||||||
| 참고사항 | For research use only |
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