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| 카탈로그 번호 | HV570014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ABCB10 (Leu492-Ala738). | ||||||||
| 타겟 | M-ABC2, ABC transporter 10 protein, Mitochondrial ATP-binding cassette 2, ATP-binding cassette sub-family B member 10, mitochondrial, ABCB10, ATP-binding cassette transporter 10 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9NRK6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | ATP-binding cassette sub-family B member 10, mitochondrial (ABCB10) is a ~79 kDa protein. ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress. Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37. In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria. 1. Tang, L. et al. (2012) British journal of haematology 157, 151-4. PMID: 22085049 2. Yano, M. (2017) Biochemical and biophysical research communications 486, 465-469. PMID: 28315685 3. Seguin, A. et al. (2017) The Journal of biological chemistry 292, 16284-16299. PMID: 28808058 4. Shum, M. et al. (2021) Science translational medicine 13. PMID: 34011630 5. Cao, S. et al. (2023) Nature communications 14, 2030. PMID: 37041204 | ||||||||
| 참고사항 | For research use only. |
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