Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP (HP849143)

Name: Anti-Human Abeta42/Beta-APP42 Recombinant Antibody (21F12), PerCP
Brand: abinScience
SKU: HP849143
Price: 268 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호	HP849143
종 반응성	Human
응용 분야	FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG1
클론 ID	21F12
접합	PerCP
타겟	Abeta42, Beta-APP42, Amyloid-beta protein 42, amyloid beta A4 precursor protein, Amyloid-beta A4 protein, Abeta 1-42
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
관련 제품	Mouse IgG1 Recombinant Isotype Control Antibody (HyHEL-10), PerCP
정제	Protein A/G purified from cell culture supernatant.
등록번호	P05067
RRID	Anti-Human Abeta42/Beta-APP42 Antibody (21F12), PerCP (abinScience Cat# HP849143, RRID:AB_3725381)
형태	Liquid
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
안정성 및 저장	The antibody solution should be stored between 2 to 8°C in dark. DO NOT FREEZE!
배경	Amyloid-beta precursor protein (Abeta 42/Beta-APP 42) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. 1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912 2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754 3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.