中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HP164014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ACAD9 Polyclonal Antibody (HP164014) is a rabbit polyclonal antibody detecting ACAD9 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ACAD9 (Thr11-Asn429). | ||||||||
| 타겟 | ACAD9, Acyl-CoA dehydrogenase family member 9, ACAD-9, Complex I assembly factor ACAD9, mitochondrial | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9H845 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Complex I assembly factor ACAD9, mitochondrial is a ~68 kDa protein. Together with NDUFAF1 and ECSIT, forms part of the mitochondrial complex I (MCIA),which is required for the biogenesis of respiratory Complex I (CI) and is therefore crucial for the activation of the oxidative phosphorylation system. ECSIT binding triggers a large conformational change, switching ACAD9 from a fatty acid oxidation (FAO) enzyme to a CI assembly factor. The function in CI assembly is independent of the FAO activity of the protein. As FAO enzyme, it catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Its preferred substrates are both saturated and unsaturated long-chain acyl-CoA substrates, with optimum activity toward the latter. 1. Nouws, J. et al. (2010) Cell metabolism 12, 283-94. PMID: 20816094 2. Nouws, J. et al. (2014) Human molecular genetics 23, 1311-9. PMID: 24158852 3. Formosa, LE. et al. (2020) Cell reports 31, 107541. PMID: 32320651 4. McGregor, L. et al. (2023) Nature communications 14, 8248. PMID: 38086790 5. Zhang, J. et al. (2002) Biochemical and biophysical research communications 297, 1033-42. PMID: 12359260 6. Ensenauer, R. et al. (2005) The Journal of biological chemistry 280, 32309-16. PMID: 16020546 7. He, M. et al. (2007) American journal of human genetics 81, 87-103. PMID: 17564966 8. He, M. et al. (2011) Molecular genetics and metabolism 102, 418-29. PMID: 21237683 | ||||||||
| 참고사항 | For research use only. |
문의하기
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
