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| 카탈로그 번호 | HA966014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ADGRG3 Polyclonal Antibody (HA966014) is a rabbit polyclonal antibody detecting ADGRG3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ADGRG3 (Gln21-Ser272). | ||||||||
| 타겟 | ADGRG3, PGR26, G-protein coupled receptor 97, Adhesion G protein-coupled receptor G3, GPR97, G-protein coupled receptor PGR26 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q86Y34 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Adhesion G protein-coupled receptor G3 (ADGRG3) is a ~60 kDa protein. Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins; additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. 1. Ping, YQ. et al. (2021) Nature 589, 620-626. PMID: 33408414 2. Gupte, J. et al. (2012) FEBS letters 586, 1214-9. PMID: 22575658 3. Hsiao, CC. et al. (2018) Frontiers in immunology 9, 2830. PMID: 30559745 4. Chu, TY. et al. (2022) Nature communications 13, 6385. PMID: 36302784 5. Valtcheva, N. et al. (2013) The Journal of biological chemistry 288, 35736-48. PMID: 24178298 | ||||||||
| 참고사항 | For research use only. |
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