Anti-Human APH1A Polyclonal Antibody (HP487014)

Name: Anti-Human APH1A Polyclonal Antibody
Brand: abinScience
SKU: HP487014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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개요

카탈로그 번호

HP487014

설명

Anti-Human APH1A Polyclonal Antibody (HP487014) is a rabbit polyclonal antibody detecting APH1A in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human APH1A (Asn207-Asp265).

타겟

Gamma-secretase subunit APH-1A, PSF, Presenilin-stabilization factor, APH-1a, APH1A, Aph-1alpha

정제

Purified by antigen affinity column.

등록번호

Q96BI3

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Gamma-secretase subunit APH-1A (APH1A) is a ~28 kDa protein. Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable).

1. Lee, SF. et al. (2002) The Journal of biological chemistry 277, 45013-9. PMID: 12297508

2. Luo, WJ. et al. (2003) The Journal of biological chemistry 278, 7850-4. PMID: 12522139

3. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

4. Marlow, L. et al. (2003) Biochemical and biophysical research communications 305, 502-9. PMID: 12763021

5. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

6. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335

7. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546

8. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874

9. Gu, Y. et al. (2003) The Journal of biological chemistry 278, 7374-80. PMID: 12471034

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human APH1A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human APH1A Polyclonal Antibody (HP487014)

개요

이미지

참고 문헌

데이터시트

SDS